Evolución percibida por los padres de preescolares que tartamudean que recibieron tratamiento preventivo / Perceived evolution by parents of preschoolers who stutter and received preventive treatment

Objetivo: I) Describir los resultados preliminares de un estudio sobre la evolución percibida por los padres de los niños entre los 2.11 y 5.11 años que tartamudeaban, después de recibir tratamiento preventivo de tartamudez con apoyo de los progenitores, II) conocer los recursos comunicativos aprendidos por los niños y sus padres respecto al tartamudeo y III) descubrir el grado de satisfacción de los padres con el tratamiento. El estudio se realizó en ILD, centro especializado en trastornos de fluidez. Método: Se administró un cuestionario a 18 padres, cuyos hijos habían sido dados de alta después de la terapia. El 77.8% (n=14) de los participantes fueron niños y el 22.2% (n=4) niñas. Los niños seleccionados que participaron en el estudio tenían una edad comprendida entre cuatro y ocho años (M=5.90, DT=1.25). Resultados: En las respuestas cabe destacar que: I) El 88.9% de los niños mantuvieron un habla fluida, II) y el 72.2% no presentó ni tuvo bloqueos, el 82.3% no experimentó tensión en la garganta, III) los niños mostraron disfluencias cuando estaban cansados (n=6) o estresados (n=5), IV) los niños mejoraron en el habla, en la conducta y adoptaron buenas estrategias ante las disfluencias o los bloqueos, V) tanto los niños como los padres utilizaron los recursos aprendidos durante el tratamiento, VI) se realizaron sesiones individuales de padres y de seguimiento y la mayoría de ellos recibió pautas a seguir en caso de recaídas, y VII) el 94.4% de los padres, quedaron satisfechos con los resultados del tratamiento. Conclusión: Los resultados preliminares indican que el tratamiento realizado con los niños preescolares con apoyo de sus padres ayudó a mejorar la fluidez del habla, su conducta, las actitudes positivas en la conversación y las habilidades de comunicación padres-hijo.(AU)

Aim: The aim of this article is (a) to describe the progress perceived by parents of children between the ages of 2.11 and 5.11 who stuttered, after receiving preventive treatment for stuttering with parental support; (b) to assess the communicative resources learned by the children and their parents regarding stuttering and (c) to find out their level of satisfaction with treatment. The study was carried out at ILD, a specialized centre for fluency disorders. Methods: A questionnaire was administered to 18 parents, whose children had been discharged after therapy. Of the sample, 77.8% (n=14) were boys and 22.2% (n=4) girls. The selected children participating in the study were aged between 4 and 8 years (M=5.90, SD=1.25). Results: From the responses it was noted that: (I) 88.9% of the children maintained fluent speech; (II) and 72.2% did not present or have blocks, 82.3% did not experience throat tension; (III) the children continued to present disfluencies when they were tired (n=6) or stressed (n=5); (IV) the children improved in speaking, behavior and had adopted good strategies in dealing with disfluencies or blocks; (V) both children and parents frequently used the resources learned during treatment; (VI) individual parent and follow-up sessions were conducted and most of them received guidelines to follow in case of relapses; and (VII) 94.4% of parents were satisfied with treatment outcomes.Conclusion: Results indicate that the treatment conducted with the preschool children, with support from their parents, contributed to improvements in speech fluency, behavior, positive conversational attitudes, and parent–child communication skills.(AU)

Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis.

High-risk endometrial cancer has poor prognosis and is increasing in incidence. However, understanding of the molecular mechanisms which drive this disease is limited. We used genetically engineered mouse models (GEMM) to determine the functional consequences of missense and loss of function mutations in Fbxw7, Pten and Tp53, which collectively occur in nearly 90% of high-risk endometrial cancers. We show that Trp53 deletion and missense mutation cause different phenotypes, with the latter a substantially stronger driver of endometrial carcinogenesis. We also show that Fbxw7 missense mutation does not cause endometrial neoplasia on its own, but potently accelerates carcinogenesis caused by Pten loss or Trp53 missense mutation. By transcriptomic analysis, we identify LEF1 signalling as upregulated in Fbxw7/FBXW7-mutant mouse and human endometrial cancers, and in human isogenic cell lines carrying FBXW7 mutation, and validate LEF1 and the additional Wnt pathway effector TCF7L2 as novel FBXW7 substrates. Our study provides new insights into the biology of high-risk endometrial cancer and suggests that targeting LEF1 may be worthy of investigation in this treatment-resistant cancer subgroup.

Using Machine Learning Technology (Early Artificial Intelligence-Supported Response With Social Listening Platform) to Enhance Digital Social Understanding for the COVID-19 Infodemic: Development and Implementation Study.

BACKGROUND: Amid the COVID-19 pandemic, there has been a need for rapid social understanding to inform infodemic management and response. Although social media analysis platforms have traditionally been designed for commercial brands for marketing and sales purposes, they have been underused and adapted for a comprehensive understanding of social dynamics in areas such as public health. Traditional systems have challenges for public health use, and new tools and innovative methods are required. The World Health Organization Early Artificial Intelligence-Supported Response with Social Listening (EARS) platform was developed to overcome some of these challenges. OBJECTIVE: This paper describes the development of the EARS platform, including data sourcing, development, and validation of a machine learning categorization approach, as well as the results from the pilot study. METHODS: Data for EARS are collected daily from web-based conversations in publicly available sources in 9 languages. Public health and social media experts developed a taxonomy to categorize COVID-19 narratives into 5 relevant main categories and 41 subcategories. We developed a semisupervised machine learning algorithm to categorize social media posts into categories and various filters. To validate the results obtained by the machine learning-based approach, we compared it to a search-filter approach, applying Boolean queries with the same amount of information and measured the recall and precision. Hotelling T2 was used to determine the effect of the classification method on the combined variables. RESULTS: The EARS platform was developed, validated, and applied to characterize conversations regarding COVID-19 since December 2020. A total of 215,469,045 social posts were collected for processing from December 2020 to February 2022. The machine learning algorithm outperformed the Boolean search filters method for precision and recall in both English and Spanish languages (P<.001). Demographic and other filters provided useful insights on data, and the gender split of users in the platform was largely consistent with population-level data on social media use. CONCLUSIONS: The EARS platform was developed to address the changing needs of public health analysts during the COVID-19 pandemic. The application of public health taxonomy and artificial intelligence technology to a user-friendly social listening platform, accessible directly by analysts, is a significant step in better enabling understanding of global narratives. The platform was designed for scalability; iterations and new countries and languages have been added. This research has shown that a machine learning approach is more accurate than using only keywords and has the benefit of categorizing and understanding large amounts of digital social data during an infodemic. Further technical developments are needed and planned for continuous improvements, to meet the challenges in the generation of infodemic insights from social media for infodemic managers and public health professionals.

A comprehensive experimental study of the influence of temperature on urban road traffic noise under real-world conditions.

The effect of road traffic noise in urban environments is an issue of social and scientific interest, due to its public health and economic impacts. Scientific literature showed a decrease in the level of tyre/road noise generated as temperature increases, but usually under standardised traffic conditions in non-urban environments. Based on a wide network for the hourly monitoring of road traffic flow, air temperature and noise levels across the city of Madrid (Spain), this work proposes and applies a new experimental methodology for studying the dependence of urban road traffic noise on temperature. This study was conducted under real-world traffic conditions involving a wide variability in urban configurations and in the type and state of preservation of vehicles, tires and pavements. From the analysis of data for a whole year, a time interval was identified (from Tuesday to Thursday and between 8 a.m. and 8 p.m.) in which the variability in road traffic flow for the whole city of Madrid was stable enough to allow for a linear regression study between temperature and noise levels from urban road traffic. The relationships found were highly significant (p ≤ 0.001) for data from all the noise monitoring stations, with values of higher than 20% and up to 42% for the explanation of the variability in the measured noise levels by temperature at most of the measurement points. The values of the slope coefficients at the noise monitoring stations ranged from -0.036 to -0.125 dB/°C, with an average value of -0.090 ± 0.011 dB/°C. These results are within the range of values reported in the scientific literature for experimental tests conducted under conditions of controlled or free-flowing traffic.

Mechanical, rheological and structural properties of fiber-containing microgels based on whey protein and alginate.

Dietary fiber (DF) - inulin (IN), bacterial cellulose nanofibers (BC), crystalline cellulose (CC) and oat fiber (OF) - were added at a concentration of 5% (2.5% for OF) to a whey protein isolate (WPI)/sodium alginate (NaAlg) dispersion. Gel microparticles (GMP) were formed by cold gelation followed by mechanical shearing. Compression stress-strain curves of bulk gels were similar for GMP-CC and GMP-OF but different from GMP-IN and GMP-BC. The soluble fiber IN did not change the aggregated matrix of the parent WPI/NaAlg gel, while other sources of DF became incorporated into the microgel matrix. Rheological tests (20 °C) revealed that GMP with added DF had a predominantly elastic behavior. Texture profile analysis suggested that GMP and GMP-IN had advantages over a commercial thickener in terms of adhesiveness and cohesiveness. GMP with added DF may find applications in foods for the elderly as texturizer and/or a carrier of fiber.

Properties of microparticles from a whey protein isolate/alginate emulsion gel.

Designing soft, palatable and nutritious texture-modified foods for the elderly is a challenge for food technologists. The aim of this work was to produce and characterize emulsion-gelled microparticles (EGM) made from whey protein isolate (WPI) and sodium alginate (NaAlg) that may be used to modify the rheology of liquid foods and as carriers of lipids and lipophilic nutrients and bioactives. Olive oil microdroplets became embedded in the WPI/NaAlg gel matrix in the form of an emulsion produced by ultrasound (US) or high-speed blending (HSB). Oil microdroplets were obtained by US and HSB, with an average equivalent diameter varying between 2.0-3.2 µm and 4.5-6.7 µm, respectively. Oil incorporation increased compression stress of bulk emulsion gels at small deformations compared to the no-oil microgel, but this effect was reversed at high strains. EGM were prepared by shear-induced size reduction. Rheological tests at 20 ℃ and 40 ℃ showed that US-EGM and HSB-EGM exhibited a predominant elastic behavior, with G' > G″ throughout the frequency range. However, when HSB-EGM were heated at 60 ℃ their rheological behavior changed to a more fluid-like condition, but not that of US-EGM. Consequently, EGM have the properties needed to improve food texture for people with masticatory/swallowing dysfunctions or needing special nutrition.

La promoción de estilos de vida saludable aprovechando los espacios públicos / Promotion of healthy lifestyles taking advantage of public spaces / A promoção de estilos de vida saudáveis aproveitando os espaços públicos / La promotion de modes de vie sains en tirant profit des espaces publics

Resumen Objetivo: Analizar la influencia que tienen el entorno físico y los aspectos sociales de los espacios públicos en la activación física y el bienestar de los ciudadanos, con el fin de identificar oportunidades para diseñar estrategias de mercadotecnia social que fomenten la salud y el bienestar entre los ciudadanos. Materiales y métodos: Se realizó un estudio mixto en dos etapas: observación y análisis de los atributos físicos de la Ruta Recreativa de Saltillo, Coahuila en base al modelo de Servipanoramas; aplicación de encuestas en línea a 168 adultos utilizando las escalas de bienestar percibido y de valoración de las Ciclovías. Resultados: Los hallazgos sugieren que la existencia de espacios públicos apropiados para ejercitarse y convivir con otros resulta atractiva para los participantes en el estudio, quienes señalan que la Ruta Recreativa estudiada ofrece el entorno adecuado para alcanzar sus metas de salud y relacionarse con personas con intereses similares. Conclusiones: Existe un interés de los visitantes a la Ruta Recreativa de Saltillo, Coahuila por alcanzar mejores niveles de salud y bienestar, lo cual puede ser aprovechado por empresas y organismos públicos para diseñar e implementar estrategias e intervenciones de mercadotecnia social orientadas a la promoción de la salud y el cambio de hábitos, utilizando los espacios abiertos que la Ruta Recreativa ofrece y llegar así a un mayor número de ciudadanos.

Abstract Objective: To analyze the influence of physical environment and social aspects of public spaces on the physical activation and well-being of citizens, in order to identify opportunities to design social marketing strategies that promote health and wellbeing among citizens. Materials and methods: A mixed study was carried out in two stages: observation and analysis of the physical attributes of the Saltillo Recreational Route, Coahuila based on the Servipanoramas model; Application of online surveys to 168 adults using the perceived well-being and assessment scales of the Ciclovias. Results: The findings suggest that the existence of appropriate public spaces to exercise and coexist with others is attractive to the participants in the study, who point out that the recreational route studied offers the right environment to reach their health goals and interact with people with similar interests. Conclusions: There is an interest of the visitors to the Recreational Route of Saltillo, Coahuila for achieving better levels of health and well-being, which can be used by companies and public bodies to design and implement strategies and interventions of social marketing oriented to the promotion of Health and change of habits, using the open spaces that the Recreational Route offers and reach a greater number of citizens.

Resumo Objetivo: Analisar a influência que tem o meio físico e os aspetos sociais dos espaços públicos na atividade física e no bem-estar dos cidadaos, com o fim de identificar oportunidades para desenhar estratégias de marketing social que fomentem a saúde e o bem-estar dos cidadaos. Materiais e métodos: Foi realizado um estudo misto em duas etapas: observação e análise dos atributos físicos da "Ruta Recreativa de Saltillo, Coahuila" tendo por base o modelo de Servipanoramas; aplicação de inquéritos a 168 adultos utilizando as escalas de bem-estar percebido e de valorização das ciclovias. Resultados: Foi sugerido que a existencia de espa9os públicos apropriados para fazer exercício e conviver com outras pessoas, resulta atractivo para os participantes no estudo. Estes assinalaram que a rota recreativa estudada oferece o ambiente adequado para alcaçar as suas metas de saúde e relacionar-se com pessoas com intereses similares. Conclusões: Existe un interesse dos visitantes pela "Ruta Recreativa de Saltillo, Coahuila", porque permite alcafar melhores níveis de saúde e de bem-estar. Este facto pode ser aproveitado por empresas e organismos públicos para desenhar e implementar estratégias de marketing social orientadas para a promoção da saúde e para a mudança de hábitos, utilizando os espaços ao ar libre que a rota oferece.

Résumé Objectif: Analyser l'influence de l'environnement physique et des aspects sociaux des espaces publics sur l'activation physique et le bien-etre des citoyens afin d'identifier les possibilités de concevoir des stratégies de marketing social pour promouvoir la santé et le bien-etre parmi les citoyens. Matériels et méthodes: Une étude mixte a été réalisée en deux étapes: observation et analyse des caractéristiques physiques de la Ruta Recreativa de Saltillo (Itinéraire Récréatif de Saltillo), dans l'état de Coahuila, d'apres le modele de Servipanoramas; et application d'enquetes en ligne a168 adultes en utilisant les échelles de bien-etre per9u et d'évaluation des pistes cyclables. Résultats: Les résultats suggerent que l'existence d'espaces publics appropriés pour réaliser des activités physiques et partager du temps avec d'autres personnes est attrayante pour les participants a l'étude. Ceux-ci indiquent que la Ruta Recreativa étudiée offre l'environnement approprié pour atteindre leurs objectifs de santé et interagir avec des personnes ayant des intérets similaires. Conclusions: Il existe un intéret des visiteurs de la Ruta Recreativa de Saltillo, Coahuila, pour améliorer leur santé et leur bien-etre. Les entreprises et les organismes publics peuvent en profiter pour concevoir et mettre en reuvre des stratégies et des interventions de marketing social visant a promouvoir la santé et le changement de comportement en utilisant les espaces ouverts qu'offrent la Ruta Recreativa pour qu'un plus grand nombre de citoyens en bénéficient.

Omnivory of an Insular Lizard: Sources of Variation in the Diet of Podarcis lilfordi (Squamata, Lacertidae).

Through 17 years and from a sample of 7,790 faecal pellets and 26,346 prey items, we studied the diet of the Balearic lizard Podarcis lilfordi in Aire Island (Menorca, Balearic Islands, Spain). We analysed the diet in terms of prey frequencies, as well as by their volume and biomass contributions. The diet of the Balearic lizard was extremely variable through the years, months and areas under study. The dominance of small clumped prey, particularly ants, was confirmed. However, the main contribution by volume corresponded to beetles, with a relevant role for Diplopoda and terrestrial Isopoda during some months and at particular areas of the island. Several prey items were probably captured at the base of shrubs, under stones or inside rock crevices. Therefore, our estimations of electivity would only be reliable for epigeal and flying prey. The capacity of the Balearic lizard to include marine subsidies in its diet, such as coastal crustaceans, is noteworthy. Also, its consumption of carrion from carcasses of gulls and rabbits and leftovers from human visitors is remarkable. Juvenile conspecifics can also be a sporadic food resource, especially during the second half of summer, whereas the consumption of vegetal matter is constant for each whole year. The shifts of vegetal exploitation among areas of the island and months take place according to availability of different plant species at each area or during a given period. Thus, lizards are able to conduct a thorough monitoring of plant phenology, exploiting a large variety of plant species. Omnivory does not imply the indiscriminate inclusion of any edible food in its diet. Rather, the inclusion of several food items means the adoption of a wide range of foraging behaviours adapted to the exploitation of each food resource.

Vernix caseosa peritonitis: report of two cases.

Vernix caseosa peritonitis is a rare complication caused by inflammatory response to amniotic fluid spilled into the maternal peritoneal cavity. Most cases occur after cesarean section. We discuss herein two patients, aged 33 and 29 years, who presented with vernix caseosa peritonitis seven to nine days after a cesarean delivery. Laparotomy was performed and it revealed neither uterine rupture nor other surgical emergencies, but cheesy exudates on the serosal surface of all viscera. Appendicectomy was performed. Histopathologic study revealed acute fibrinous serositis and a mixed cellular infiltrate, rich in neutrophils, around fetal desquamated anucleate squamous cells. Patients´ recovery was complete. Clinical diagnosis of vernix caseosa peritonitis should be suspected in patients presenting post-cesarean section with an acute abdomen. Distinctive histopathologic findings allow making the correct diagnosis. Vigilant monitoring after diagnosis is essential as delayed morbidities may appear.

Caso Clínico: Evaluación e Intervención en un Caso de Ansiedad por Separación de una Niña Adoptada / Clinical Case: Assessment and Intervention in a Case of Separation Anxiety in an Adopted Child

Se describe el caso de una niña 3, 1 años de edad adoptada en Nepal que presenta ansiedad de separación, problemas de conducta y de vinculación, especialmente durante el último año. Estas dificultades interfieren negativamente en la dinámica familiar. Se realiza un diagnostico de las dificultades de la niña por medio de una entrevista clínica, instrumentos de observación de la conducta y pruebas estandarizadas. Con los padres se utilizaron instrumentos de observación en sesión y registros conductuales en relación a sus respuestas ante las conductas problemáticas de la niña. Se llevó a cabo una intervención basada en el entrenamiento cognitivo conductual de los padres con la niña, con técnicas operantes y desde una perspectiva del desarrollo emocional y del establecimiento de vínculo. Se describe la evolución del problema y el seguimiento del caso (AU)

In this study, the case of a 3 year-old girl adopted from Nepal is reported. The child had been suffering separation anxiety and attachment problems, especially over the previous year. These difficulties were interfering negatively in the family dynamics. A diagnosis is made of the child’s difficulties through a clinical interview, observation instruments and conduct standardized testing. Observation instruments were used in sessions with the parents, as were records of behavioral response from the adoptive parents in relation to the child’s behavioral problems. The intervention was based on parent management training with the girl, with operant techniques and from an emotional development and attachment perspective. It describes the evolution of the problem and the case follow-up (AU)

Normative data for semantically associated Spanish word lists that create false memories.

The present study provides norms for Spanish word lists that have been used to create false memories in native speakers of Spanish. The word lists reported are based on the Roediger and McDermott (1995) lists that have been used extensively to examine illusory memories. We employed Roediger and McDermott's critical lures, translated them into Spanish, and created semantically associated Spanish word lists by testing native Spanish speakers. The resulting lists were then normed with additional native Spanish speakers. Overall, the participants recalled 53% of the list items and 32% of the critical lures with the word lists developed. In addition, 74% of the list items and 69% of the critical lures were recognized by the participants. The present study adds to the literature by providing a set of Spanish lists that can be used by researchers interested in evaluating false memories in individuals who speak Spanish. These norms may be downloaded from www.psychonomic.org/archive.

Characterization of bacterial pectinolytic strains involved in the water retting process.

Pectinolytic microorganisms involved in the water retting process were characterized. Cultivable mesophilic anaerobic and aerobic bacteria were isolated from unretted and water-retted material. A total of 104 anaerobic and 23 aerobic pectinolytic strains were identified. Polygalacturonase activity was measured in the supernatant of cell cultures; 24 anaerobic and nine aerobic isolates showed an enzymatic activity higher than the reference strains Clostridium felsineum and Bacillus subtilis respectively. We performed the first genotypic characterization of the retting microflora by a 16S amplified ribosomal DNA restriction analysis (ARDRA). Anaerobic isolates were divided into five different groups, and the aerobic isolates were clustered into three groups. 84.6% of the anaerobic and 82.6% of the aerobic isolates consisted of two main haplotypes. Partial 16S rRNA gene sequences were determined for 12 strains, representative of each haplotype. All anaerobic strains were assigned to the Clostridium genus, whereas the aerobic isolates were assigned to either the Bacillus or the Paenibacillus genus. Anaerobic isolates with high polygalacturonase (PG) activity belong to two clearly distinct phylogenetic clusters related to C. acetobutylicum-C. felsineum and C. saccharobutylicum species. Aerobic isolates with high PG activity belong to two clearly distinct phylogenetic clusters related to B. subtilisT and B. pumilusT.